6.Measuring Biological Response to Curcumin (Posted: 03/06/2007) - In this trial, researchers are exploring the ability of a substance called curcumin to affect biomarkers associated with precancerous lesions in the colons of smokers. 7.Combining Targeted Therapies for Metastatic Colorectal Cancer (Posted: 08/15/2006, Updated: 02/06/2007) - In this trial, researchers are combining the targeted monoclonal antibody cetuximab (Erbitux) with another targeted drug called sorafenib (Nexavar) to treat patients with metastatic colorectal cancer whose tumors show epidermal growth factor receptor (EGFR) activity. 8.Gene Therapy for Metastatic Cancer (Posted: 11/21/2006) - In the trial, researchers will harvest normal T lymphocytes from patients' blood and modify these immune system cells to recognize p53 protein, a common hallmark of many cancers. The modified cells will be enriched in the laboratory and then infused back into the patients. 9.Treatment Based on Colorectal Tumor Protein Level (Posted: 11/14/2006) - In this clinical trial, researchers will measure the level of a protein called thymidylate synthase (TS) in the tumors of patients with metastatic colorectal cancer and assign patients to one of two treatment groups based on their TS levels. 10.Monoclonal Antibodies for Metastatic Colorectal Cancer (Posted: 09/19/2006) - In this trial, patients will receive one of two targeted agents, or a combination of the two, that were recently approved by the U.S. Food and Drug Administration for use with combination chemotherapy in the treatment of metastatic colorectal cancer.
