1.Herbal Therapy for Brain Cancer (Posted: 06/12/2007, Updated: 02/21/2008) - In this trial, patients with high-grade glioma will be randomly assigned to take an herbal preparation of Boswellia serrata (frankincense) and undergo standard treatment for six months or undergo standard treatment alone for six months. Researchers want to see the addition of herbal therapy can help relieve brain swelling in these patients. 2.Chemotherapy for Recurrent Gliomas (Posted: 02/14/2006, Updated: 11/07/2007) - In this clinical trial, researchers are testing a new drug called enzastaurin in patients whose glioma has recurred after previous radiotherapy and chemotherapy. 3.Zactima for Recurrent or Progressive Brain Tumors (Posted: 11/28/2006) - This phase I/II trial will help scientists determine the dosage for the brain cancer drug Zactima in patients taking antiseizure medications called EIAEDs and will examine the antitumor effects of Zactima in patients not taking EIAEDs. 4.New Strategy for Treatment-Resistant Solid Tumors in Children (Posted: 06/13/2006) - This clinical trial will assess the safety of of a drug called talabostat in combination with chemotherapy in pediatric patients with cancer who have not responded to or gotten worse after other treatments. 5.Therapy for Treatment-Resistant or Recurrent Gliomas (Posted: 05/03/2005) - This trial will determine the maximum dose of CC8490 that can be given to patients and will assess the safety and tolerability of this drug. Additionally, researchers hope to determine the mechanism by which CC8490 affects glioma cells.
