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Featured Clinical Trials Supported by the National Cancer Institute

Today, hundreds of cancer clinical trials are under way in the United States. Clinical trials answer vital research questions that lead to better screening, prevention, diagnosis, and treatment options for all cancers. This section highlights NCI-supported cancer trials featured in the NCI Cancer Bulletin and demonstrates the breadth of clinical cancer research supported by the NCI.

To find other cancer trials open to enrollment:

  • Call the National Cancer Institute’s Cancer Information Service at 1-800-4-CANCER (1-800-422-6237) for information about trials all across the country. The call is toll-free and completely confidential.
  • Use the basic PDQ search form to look online for trials listed in NCI's clinical trials database. The top of the form has a Help link for tips about searching for clinical trials.
  • For information about cancer trials taking place on the National Institutes of Health campus in Bethesda, Maryland, call the National Cancer Institute’s Clinical Studies Support Center at 1-888-NCI-1937 (1-888-624-1937). The call is toll-free and completely confidential.
11.  Testing Trabectedin in Pediatric Patients
(Posted: 06/30/2009) - In this phase I clinical trial, children with solid tumors that have either recurred or have not responded to previous treatment will be treated with trabectedin.

12.  Optimizing Postoperative Chemotherapy for Breast Cancer
(Posted: 06/16/2009) - In this trial, women with early-stage breast cancer deemed by their doctors to be at high risk for recurrence will receive adjuvant chemotherapy with either cyclophosphamide and doxorubicin or paclitaxel given four times over an 8-week period.

13.  Cetuximab and Chemoradiotherapy for Locally Advanced Esophageal Cancer
(Posted: 05/19/2009) - In this trial, patients with locally advanced esophageal cancer will undergo chemoradiotherapy using the drugs cisplatin and paclitaxel, and half of them will be randomly assigned to also receive the biologic agent cetuximab.

14.  Tomotherapy for Patients with Limited Metastatic Cancer
(Posted: 04/21/2009) - In this trial, patients with limited metastatic tumors outside the brain will be treated with a type of radiation therapy called helical tomotherapy.

15.  Targeting Resistance to Endocrine Therapy in Advanced Breast Cancer
(Posted: 04/07/2009) - In this phase III clinical trial, women with advanced, hormone receptor-positive breast cancer will be randomly assigned to receive hormonal therapy (with letrozole or tamoxifen) and either bevacizumab or a placebo.
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