1.Sorafenib for Kaposi's Sarcoma (Posted: 01/30/2007) - In this trial, patients with either AIDS-related or non-AIDS-related Kaposi's sarcoma (KS) will be treated with varying doses of the drug sorafenib (Nexavar®) for up to 54 weeks to examine the safety of the drug and determine how it is processed in patients with KS who are receiving antiretroviral therapy. 2.Treatment for Castleman Disease (Posted: 12/13/2005) - In this clinical trial, symptomatic patients with multicentric Castleman disease (MCD) will be treated with the antiviral drugs high-dose zidovudine (HDAZT) and valganciclovir. These drugs are converted into toxic compounds by KSHV-encoded proteins. Patients who do not respond to this treatment will also receive the drug bortezomib to see if it can increase the ability of KSHV to activate HDAZT and valganciclovir and increase tumor cell death. 3.Biological Therapy to Treat Kaposi Sarcoma (Posted: 08/03/2004) - Researchers with this study are investigating whether bevacizumab (Avastin®), a type of biological agent that blocks the formation and growth of new blood vessels, is effective in the treatment of Kaposi sarcoma (KS). Blood vessel cells are the main component of KS lesions. 4.Topical Treatment for HIV-Related Kaposi Sarcoma (Posted: 04/20/2004) - This trial investigates whether the experimental drug halofuginone is effective and safe in the treatment of Kaposi sarcoma, the most common cancer in patients infected with HIV.
